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Hypothermia and life-threatening cardiovascular conditions may occur, or serious pathological consequences (muscles, liver, kidneys, heart, brain...)

the atmosphere in the vessel can be, for example, sterile clean air or sterile clean nitrogen gas

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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

Federation Proceedings , 41 (9), 25772582

PMID: 30193299