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Among other things the application of 4-hydroxynonenal to keratinocytes started a multitude of cellular responses such as an up-regulation of anti-oxidative enzymes (heme oxygenase-1 (HO-1), catalase, NADPH:quinone oxidoreductase (NQO1), and glutathione S-transferases), activation of several kinases such as Erk1/2, JNK and p38 and PI3 and a translocation of the transcription factor Nrf2 to the nucleus [358]

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PMID: 29596003

4d), which indicates that the O -antigen chains do not appear to significantly hinder the accumulation levels of these specific molecules

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If cystine is in your urine, it may smell like rotten eggs