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2.3.3 Molecular pathogenesis and disease mechanisms The development of ALS is driven by several overlapping biological mechanisms that together cause motor neuron degeneration

NeuroImage 43:756763 Freedman RR, Johanson CE, Tancer ME (2005) Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

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Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)

308,309 PUFAs can be oxidized by singlet oxygen, resulting in the formation of hydroperoxides in a process called photosensitized oxidation

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