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Groups 4, 5, 6, 7: These groups were received IP injection of vitamin B 12 at doses of 25, 50, 100 and 200 g kg -1 , respectively, for 10 consecutive days after surgically-induced crush injury in tibial nerve and served as crush plus vitamin B 12 groups

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L-NAME+L-arginine (combined) exhibited a decrease in bleeding amount and laboratory values in comparison to controls (amputation only) or control-heparin and control-warfarin groups

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Relative to control subjects, plasma IL1 concentrations did not differ between the three groups

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