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A multicenter dose-escalation study involving 51 R/R AML patients (37 KMT2Ar) revealed good tolerability (Stein et al., 2021)

Similarly, the 337 GA polymorphism has shown associations with oxidative stress markers, primarily through elevated MDA levels seen among individuals with AA and AG genotypes in comparison with the GG genotypes

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24,30 A study of human cNF found that these tumours contain a greater abundance of mast cells and lymphatic vessels, as well as a larger lymphatic vessel diameter than several other NF-associated tumour types, thus suggesting that mast cells play a role in human cNF formation or growth