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"L-carnitine + carbohydrate and muscle fuel metabolism." J Physiol 2011;589:963-73

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What we know Some randomized controlled trials have demonstrated that addition of supplemental L-carnitine to standard medical therapy improves measures of exercise tolerance and heart pumping ability in patients with heart failure

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This viewpoint has been supported by observations of reduced mitochondrial ROS production and improved human bronchial EpiC viability with treatment using a CPT1A inhibitor, etomoxir, after CS exposure ( However, enhanced FAO and CPT expression by L-carnitine has been proven to be beneficial to emphysema or COPD (Karlic et al., 2002