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10.1016/S0165-2427(98)00111-1

doi: 10.1007/s00441-020-03267-w

Seek medical advice if cramps are severe, persistent, or accompanied by swelling, redness, weakness, or other concerning symptoms such as chest pain or breathlessness
This isn't just increased flow through existing vessels

It has an hepatic metabolism, mainly because of the glucuro-conjugation of the molecule, with the formation of inactive metabolites

Ensure it remains cool and protected from light throughout your journey
