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the KISS1 gene product, available as kisspeptin-10 or kisspeptin-54) is a naturally occurring neuropeptide that stimulates hypothalamic GnRH neurons to drive release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [1] [5]

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17 Insights, benefits, and setbacks of monoclonal antibody therapies have also been presented based on various trials

While weight loss correlates with steatohepatitis resolution, the relationship is imperfect, and even semaglutides phase 2 trial failed to move fibrosis despite clear NASH resolution a reminder that steatosis, inflammation, and fibrosis do not always respond in lockstep