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L-acetylcarnitine in the treatment of patients with peripheral neuropathies: a short term, double-blind clinical study of 426 patients

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(2018) found that elevated cerebrospinal fluid (CSF) TMAO is associated with biomarkers of AD pathology (phosphorylated tau and phosphorylated tau/A) and neuronal degeneration (total tau and neurofilament light chain protein)

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In this review, the mechanisms underlying the hyperammonemia and neurological dysfunction in urea cycle disorders, organic acidurias, and fatty acids oxidation defects, as well as the therapeutic strategies for the ammonia control will be discussed