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However, the increase in molar ratio is entirely explained by the fact that IGF-I and IGFBP-3 increase with the same number of moles per liter, but with a larger relative increase in IGF-I than IGFBP-3 and with IGF-II molar concentrations being unchanged (112)
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Postnatal growth of mice has been shown to rely on signaling mediated by JAK2 and STAT5, downstream from the GHR (110, 255, 256)
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As we age, natural GHK levels in the body decline, from around 200 ng/mL in the plasma of a 20-year-old to roughly 60 ng/mL by age 60
