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Diabetologia 50, 202211

Figure 4 V , Voltage-gated sodium channel

These gender-specific effects may be important for the side effects of ibuprofen (such as increased risk of stroke) and more research is needed to investigate this possibility

Call Your Provider Promptly For Severe abdominal pain (possible pancreatitis) Persistent vomiting that prevents fluid intake Right-upper-quadrant pain that radiates to the back or shoulder (possible gallbladder issue) Sudden vision changes (rare, but reported) Symptoms of severe dehydration: dizziness on standing, dark urine, dry mouth For a deeper dive on what to expect over time, our side effect timeline guide walks through duration and management for each common issue

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Hydroquinone may produce exogenous ochronosis, a gradual blue-black darkening of the skin