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The copper component creates oxidation vulnerabilities that limit stability compared to other peptides

Glutathione is also considered safe, though oral absorption can be limited unless using liposomal or sublingual forms

Wheat Germ Cell-Free Platform for Eukaryotic Protein Production

doi: 10.1016/j.pnpbp.2020.109913 98

Available online: 38.Faulds D., Goa K.L., Benfield P

As used herein, "conditions which allow alkylation of the sulfhydryl group of GSH with the heavy isotopologue of the maleimide" typically require that the heavy isotopologue of the maleimide (such as d5-NEM) is (initially) present at a concentration of at least 0.001 mM, preferably at least 0.01 mM, more preferably at least 0.1 mM, even more preferably at least 1 mM, yet even more preferably at least 10 mM or even at least 50 mM