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doi:10.1210/jc.2017-01155

A scaled-up version of the system was constructed that maintained the simplicity and affordability of the prototype design, and its performance was tested in Saudi Arabia

With increasing intakes of vitamin B12, concentrations of holoTC rise continuously at least until vitamin B12 saturates the transport proteins

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

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