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Of note, KD of ALOX15 and inhibition of 15LO1 decreased GPX4 protein expression, consistent with less need for peroxidase activity

Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6