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Wong CS, Hingorani S, Gillen DL, Sherrard DJ, Watkins SL, Brandt JR, Ball A, Stehman-Breen CO: Hypoalbuminemia and risk of death in pediatric patients with end-stage renal disease

the lysine residue preceding the active site, which forms electrostatic interactions with the carboxyl group of the glycine in GSH, the active site cysteines and polar amino acids interacting with the carboxyl group of the glutamate in GSH are conserved in most ROXYs, suggesting that GSH binding might be required for activity

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63 Additional small molecules, including GS-4571, OWL833, and HD-7671, have demonstrated the ability to induce insulin secretion in animal models

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This is of particular, but not exclusive relevance, to statins, calcium channel blockers, digoxin and the blood sugar drug, metformin