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Peripheral clocks, although driven by the central clock, can be influenced by various environmental cues, such as feeding times, temperature, and physical activity [37]

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For them to be excreted from the body, they must be converted from fat-soluble to water-soluble

In this regard, the Q-SYMBIO study, a multicenter randomized placebo-controlled trial, showed that a daily intake of 300 mg of CoQ 10 ( n = 202) or placebo ( n = 218) in patients affected by moderate or severe heart failure (HF) and treated with the conventional gold standard therapy ( n = 420), have benefited from a significant reduction in major adverse cardiac events rate, cardiovascular mortality, all-cause mortality, and incidence of hospital stays for HF after 2 years in comparison with the placebo [123]