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Crucially, cancer metabolites can affect epigenetic modifications, posttranscriptional modifications, and signal transduction processes

Patel, A

Gene set and pathway enrichment analysis Sets of metabolites that were significantly different between comparison groups, or those that distinguished one group from another were assessed for pathway and functional group enrichment with the MBROLE 27 and Reactome 30 platforms, using default settings, and with metabolite classifications from Metabolon

doi: 10.1046/j.1525-1497.2001.03419.x [DOI] [PMC free article] [PubMed] [Google Scholar] 555

Keywords: hyperammonemia, inborn errors of metabolism, urea cycle, acute management, ammonia, Middle East Introduction Acute hyperammonemia is defined as elevated plasma ammonia levels associated with muscular hypotonia, seizures, vomiting, and impaired consciousness

Some patients with fatigue and cognitive disorders have a resistance to the metabolism of choline that is similar to the mechanism found in insulin resistance