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Though several protease systems have been implicated in this process, it is further identified that uPA-urokinase-type plasminogen activator receptor (uPAR) system is a central player in mediating the proteolysis during the invasion and metastasis of cancer [247]

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doi: 10.1126/science.adj3347 [DOI] [PMC free article] [PubMed] [Google Scholar] 100.Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR, Lefkowitz RJ