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Alternatively, the increase in frequency of mIPSCs in layer V pyramidal cells that we observe may be due to a higher inhibitory drive by interneurons other than those positive for PV, such as cholecystokinin, that are known to also target cell soma and proximal dendrites of these pyramidal cells, and that modulate the activity of PV cells in this region 29

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Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients