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Description
In most cases, hyperpigmentation is completely harmless
Melanotic macules may occur as a part of syndromes with multisystem anomalies as Peutz-Jeghers syndrome, Carney complex, LEOPARD syndrome, LAMB syndrome

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Some of these tumors were previously classified under Tumors of the Nervous System and Tumors of the Skin [31, 43]

MS

95% CI, 1.16~1.51) was slightly superior to LDL-C (HR = 1.28