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These effects are particularly noticeable in individuals with a B12 deficiency or conditions like chronic fatigue syndrome or anemia, where long-term treatment can significantly improve quality of life

Laboratory clues include fasting plasma glucose above diagnostic thresholds and hemoglobin A1c elevation, typically 6.5% or higher at diagnosis

The Sugimoto 1995 study documented that copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro, with 50% inhibition at 0.12 mcg copper/mL

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"The methionine-homocysteine cycle and its effects on cognitive diseases"

Some can stay even longer in liver storage to prevent disease