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Kim HJ, Kim J, Lee S, et al

ALA is considered essential because your body cant produce it

Once TMA is produced, it is absorbed into the bloodstream and transported to the liver, where the enzyme flavin-containing monooxygenase (FMO) oxidizes TMA into trimethylamine-N-oxide (TMAO)

Both the anti-fatigue and anti-oxidation effects are generally closely related in their functional metabolic pathways

Although Otto Warburgs theory of aerobic glycolysis laid the foundation for tumor metabolism research, this metabolic pathway has not been successfully exploited in the clinic, largely due to the adverse side effects and limited efficacy of 2-deoxyglucose, which inhibits glycolysis
2021;9:e04067