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Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects

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The 13 amino acid N-terminal extension further adds to the peptides shelf life and resistance to breakdown, and this 13-amino acid extension results in a dramatically extended half-life of about 20-30 hours compared to the mere minutes of native IGF-1

Boosting it could extend healthy lifespan."[13][3] He advocates for precursors but sees value in inhibitors like 5-Amino-1MQ to maximize NAD+ utility

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Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome