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GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications
Taton A
In contrast, blood levels of ketone bodies in pathological ketoacidosis can reach up to 1525 mM
Therefore, GST activity results in irreversible GSH depletion leading to decreased levels of GSH if not to de novo GSH biosynthesis
