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2017a,b), as will be discussed in section 4

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Human data for nanoparticle-enabled insulin remain limited compared with animal studies, but feasibility shown by sprays and strong preclinical work on deformable nanovesicles and nanoparticle-in-film systems support continued development of higher-payload, longer-contact nano-in-device strategies [134]

Both probiotics and prebiotics have a variety of biological actions, including outcompeting pathogenic microorganisms in the digestive tract, inactivating harmful metabolites, producing powerful bioactive molecules (short-chain fatty acids), modulating immune and metabolic signaling, improving overall digestive tract function, and enhancing central nervous system effects through the gutbrain axis

Some studies have suggested that ACO is localized at the plasma membrane (Rombaldi et al., 1994

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