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ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2

Taking the advantages of these important roles in human health, manganese-based compounds and materials have been considered as a kind of potential candidates for novel diagnosis strategy, vaccine and drug development

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The NRF2 activators are mainly divided into two classes: cysteinereactive activators and PPI disrupting activators

For instance, a previous study has proved that the MET amplification could induce cetuximab or panitumumab resistance in metastasis CRC patients without KRAS mutations (Bardelli et al., 2013)