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344,345,346 Although some studies indicate that breast cancer patients with ER expression between 1% and 10% may exhibit reduced sensitivity to endocrine therapy, the threshold of 1% ER expression is still used in most current clinical practices to determine the need for endocrine therapy

doi: 10.3390/ijms23169361 146

reduced SHBG levels enhance free androgen bioavailability and create an imbalance in folliculogenesis, ovulation and metabolic homeostasis [45]

In most cases, arrhythmia symptoms are mild, often without any symptoms at all