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Anim Sci J 91:e13357
The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot
Bioact Mater 2021;6(10):33963410
However, it has been know to also occur in childhood and as late as the 60s
Both SIRT1 and SIRT6 are measurably downregulated in older skin, and this downregulation correlates directly with reduced NAD+ availability
