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Other in vitro studies reveal that TNF- could reduce melanocyte-stimulating hormones receptor (MSH-R) binding activity, MC1R expression, and the expression of a melanosomal protein gp87, promoters of melanogenesis 141 , 142

Molina-Santiago C, de Vicente A, Romero D

2024;43(4) doi: 10.1016/j.celrep.2024.113975

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Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats

In reference to cancer, an effective amount comprises an amount sufficient to cause a tumor to shrink and/or to decrease the growth rate of the tumor (such as to suppress tumor growth) or to prevent or delay other unwanted cell proliferation in cancer