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3.3.2 Chronic progressive external ophthalmoplegia (CPEO) POLG1 is a nuclear gene that encodes mitochondrial DNA polymerase gamma, responsible for the synthesis of mtDNA

In lipopolysaccharide (LPS)-stimulated RAW 246.7 murine macrophages, an ethanolic SCOPA extract, previously found to attenuate lipolysis and markers of adipose tissue inflammation, also inhibited the expression of several inflammatory genes (72)

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The remaining cells were washed three times with PBS and transferred to 6-well plates containing cystine-free medium supplemented with unlabelled GSH