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Oral intake of L-carnitine during pregnancy should be assessed on a case-by-case basis with a physician

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These results agree with previous reports that azole efficacy declines sharply once biofilm formation has occurred, primarily due to reduced drug penetration, efflux pump activation, and metabolic dormancy of biofilm-embedded cells 38

Statistically, in healthy individuals, about 12 h after ED ingestion, there is an increase in systolic blood pressure by 610 mmHg, diastolic blood pressure by 36 mmHg, heart rate by about 37 beats/minute, and QT interval prolongation up to 2225 ms