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What proximal pharmacodynamic biomarkers should we measure
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After evaluating the peptide on aged cell cultures, the researchers apparently observed reduced senescence-associated staining and lower protein levels of p16, p21, and p53 in the remaining cell population, consistent with the removal of cells that highly expressed these markers
Das MK, Furu K, Evensen HF, Haugen P, Haugen TB
Reduction in senescent cell concentration, which otherwise contribute to inflammation and tissue damage
