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doi: 10.1080/1745039X.2017.1421340 28 TamaiIOhashiRNezuJYabuuchiHOkuAShimaneMet al

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Its principal physiological role is to transport long-chain fatty acids into the mitochondria the energy-producing structures within cells where they are broken down to generate energy

It has been widely reported that a reduction of AKT phosphorylation leads to FOXO3a activation and increased MAFbx and MuRF1 transcription, thus controlling cell survival and cell proliferation

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