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This interaction between cell aging and NAD+ reduction shows a vital link where SASP-triggered increase in CD38 disrupts cellular NAD+ balance

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This inefficient metabolism leads to the body trying to store more fat as a reserve for energy, which can lead to weight gain

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The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier