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Among the secreted factors, extracellular vesicles (EVs) and mainly exosomes have emerged as novel communication vehicles that have been detected in the TME and are increasingly understood as key players in tumor growth and spread [133,134]

Researchers at the University of Zagreb, led by Predrag Sikiric, isolated the parent gastric protein BPC from human gastric juice and identified this fragment as exhibiting cytoprotective and healing properties in animal models through the 1990s and 2000s

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"Modulatory effects of BPC 157 on the activation of the Src-Caveolin-1-endothelial nitric oxide synthase pathway." J Mol Med , 98:1361-1373, 2020

This tumor angiogenesis core gene signature also included CLEC14A and CD93, which together with endosialin and thrombomodulin constitute a C-type lectin family that are frequently up-regulated in tumor vessels [95, 101,102,103,104,105,106]