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A.AlfieriR.CaffarraC.et al (2017)

However, studies have proposed NO to represent a double-edged sword with its overproduction leading to a multitude of NO by-products implicated in mutational events and carcinogenesis

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Several GSTP1 inhibitors are currently in preclinical development, and our findings suggest that their antineoplastic activity may be potentiated through concurrent disruption of PHD2

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NO activates sGC, elevating cGMP levels, which, in turn, activate PKG
