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the absorbance at 600 nm was measured and counted as A 0

This establishes a direct and important mechanistic bridge between the classic mechanical pathogenic factor in OA and the emerging oxidative stress-mediated cell death pathway

The accumulation of myoglobin, Tamm-Horsfall proteins, and uric acid within the tubules contributes to cast formation, further obstructing tubules and inducing ischemia

Summary Keywords vitamin C, dietary supplements, antioxidants, diabetes mellitus, metabolic syndrome, cardiovascular diseases Citation Dludla PV, Nkambule BB, Nyambuya TM, Ziqubu K, Mabhida SE, Mxinwa V, Mokgalaboni K, Ndevahoma F, Hanser S, Mazibuko-Mbeje SE, Basson AK, Sabbatinelli J and Tiano L (2022) Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased risk of cardiovascular disease: A systematic review of randomized controlled trials

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Chondrocyte matrix synthesis Proteoglycan production: Chondrocytes synthesize aggrecan (large proteoglycan) providing cartilage's compressive resistance