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Some patients may require an even higher dose of 2 mg weekly for optimal effect, particularly for weight management indications, though this should be approached cautiously with careful monitoring for adverse effects
doi: 10.1002/cbic.201500312
Dosing does not typically require gender-based adjustment, though individual response should always guide protocol modifications
Why no big human trials: Peptides cant be patented, so pharmaceutical companies wont fund the $100M+ studies needed for FDA approval
Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)
PMID: 30321019
