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Nutrients 10 , 1605 (2018)
The restricted expression of PC in astrocytes was first demonstrated in primary cultures (Yu et al
Author contributions AC, NS, and SK contributed to conception and design of the study
ClinicalTrials.gov registry search: mecasermin (native recombinant human IGF-1)
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The causative mutations fall into two categories: (1) 0 mutations, associated with absent -globin synthesis, and (2) + mutations, characterized by reduced (but detectable) -globin synthesis
