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For researchers undertaking preliminary or exploratory work, smaller quantities may be appropriate

20JG034), Scientific Research Foundation 2019 for the Returned Overseas Scholars of Shaanxi Province and High-level Talent Programs of Shaanxi Province

Neutrophil transepithelial migration and epithelial barrier function in IBD: potential targets for inhibiting neutrophil trafficking

To provide insight into the complex metabolic reprogramming crucial in chondrocytes during OA progression, we investigate the dynamic interaction between metabolic pathways, such as glycolysis, lipid metabolism, and mitochondrial function

Importantly, non-tumorigenic variants of FGF19, such as M52/M70/NGM282 (aldafermin),130 131 have been developed which can be used therapeutically with beneficial effects on metabolism without promoting or perhaps even counteracting carcinogenesis.132 133 The FGF19 mimetic M70/NGM282 improved liver injury in the Mdr2/Abcb4 / mouse model of sclerosing cholangitis.130 Moreover, M52, protected Mdr2/Abcb4 / and Fxr / mice from spontaneous hepatic fibrosis, cellular proliferation and HCC formation.134 In patients with PBC with insufficient response to UDCA NGM282/aldafermin mildly improved cholestatic liver enzymes, but mainly gastrointestinal side effects such as diarrhoea, abdominal pain and nausea (but not pruritus) were observed131 (table 1)