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Yeast cells which obtain energy through aerobic respiration have extremely active mitochondria, organelles in which key pathways of aerobic respiration take place (the TCA cycle and oxidative phosphorylation associated with the respiratory chain)
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In the structures of nickel or cobalt-activated IdeR complex with mbtA-mbtB operator DNA, two homodimers of IdeR are bound to the opposite side of the DNA duplex, forming a double-dimer complex, in which the DNA duplex adopts a distorted B -DNA conformation with three complete helical turns, and metal-binding sites 1 and 2 completely occupied (Fig
A serious clinical complication in these patients is the progressive and frequently late-onset dementia noted in this disorder
