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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

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Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

By improving local and general blood flow, the peptide is posited to exert stomach cell protection against ischemia and damaging agents, therefore facilitating gastrointestinal tract healing