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10.1111/j.1526-4610.2009.01484.x Headache J

(2000) 440:R0468

10.1186/s13024-021-00450-7 Mol

We know they enhance muscle, neuronal, and bone growth while simultaneously preventing atrophy

Similarly, PAT-1251 would inhibit both LOXL2 and LOXL3 at 10 M (IC 50 (LOXL2) = 0.87 M, IC 50 (LOXL3) = 1.38 M), but inhibit less than 10% inhibition of diamine oxidases (hDAO) and monoamine oxidase (hMAO) 41

The TGF-1/Smad3 pathway is a key driver of this process, inducing the expression of fibrotic markers such as -SMA and collagen I, promoting interstitial remodeling