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binds GLP-1 receptors on pancreatic -cells (stimulating glucose-dependent insulin secretion), -cells (suppressing glucagon), gastrointestinal tract (slowing gastric emptying), and hypothalamic neurons (suppressing appetite and food intake via arcuate nucleus signaling)

I recommend starting conservatively with 0.25 mg daily for the first week regardless of injury severity

Acknowledgements We acknowledge the AAV Core Facility of Academia Sinica for generating recombinant AAV (Grant AS-CFII112-204)

Despite their clinical heterogeneity, these disorders share convergent pathological drivers, including oxidative stress, chronic inflammation, hormonal dysregulation, metabolic dysfunction, aberrant extracellular matrix (ECM) remodeling, and impaired apoptosis (Kumar and Ramanarayanan, 2025)

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