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Exenatide, released in 2005 as Byetta, is the oldest GLP analog

doi: Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C

Calorie restriction activates AMPK in intestinal stem cells and increases NAD + levels by stimulating Nampt transcription

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GLP-1 drugs are designed to work at certain doses to achieve optimal receptor saturation