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Targeting astrocytic metabolism holds immense potential for the development of therapeutic interventions targeting metabolic abnormalities

In the CNS, GSH is synthesized primarily by astrocytes and transported to neurons, where it provides oxidative resistance (Dringen and Arend, 2025)

10.1073/pnas.0406547102 [DOI] [PMC free article] [PubMed] [Google Scholar] Yi L, Donsante A, Kennerson ML, Mercer JFB, Garbern JY, & Kaler SG (2012)

The rationale is straightforward: these peptides work through complementary mechanisms, and together they may address more aspects of disc healing than either can alone

Despite the facts that glutathione is widely available, the efficacy and safety profiles of systemic glutathione have yet to be fully understood

Mattison J