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Oncogene 21 , 48634871 (2002)

This approach covers both the penetration limitation of topical and the lack of clinical data for injectable by using each route where it has the strongest rationale

The commonly referenced therapeutic range of 0.25-0.5 mg daily (250-500 mcg) extrapolates from the effective rat dose of approximately 10 mcg/kg body weight

However, the net effect depends on overall biological context, regulatory mechanisms, and timing

Actinomycin-X2-Immobilized Silk Fibroin Film with Enhanced Antimicrobial and Wound Healing Activities
