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Description
During the development of ALD, numerous pathways in the liver are modulated by alcohol, many through mechanisms involving oxidative stress 3

Genuine choline deficiency contributes to hepatic fat accumulation which is exactly why choline is in the blend and why the fat-metabolism story sounds plausible

Small RNA: can RNA interference be exploited for therapy

In people with CKD, phosphorus can build up to unhealthy levels and deleteriously affect bones, making them weak and prone to fracture

The following diagrams shows some of these reasons

doi: 10.1038/s41467-018-06349-0 10 DuJ