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Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

Consistent with this general mechanism, oxidative stress is a major proposed pathogenic mechanism for neurodegenerative disorders in which mitochondrial defects have been reported, including Parkinsons, Huntingtons, and Alzheimers diseases

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Thyrotropin receptor autoantibodies induce human thyroid cell growth and c-fos activation

Some patients opt for a nutrient-rich IV beforehand to prepare their bodies for optimal results
