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Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, Epstein CJ, Ho YS, Richardson A

doi: 10.1016/j.rvsc.2017.01.016

A recent study exploring cysteine metabolism in cocaine self-administering rats found that 185 mg/Kg of cocaine (intravenous) led to an increase in reactive sulfur species in kidneys, which remained significantly high following 10-day abstinence, indicating that cocaine shifted cysteine metabolism to an anaerobic pathway [108]
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In addition, the authors carried out in vitro glucose uptake assays using HepG2 and 2-NDBG

Early reports suggest its well-tolerated, but long-term safety is still being evaluated
